化学与成员科学高校,生物物理动态探讨所集团

二零一三年2月一日,伊Stan布尔大学(University of Chicago)化学系教师、生物物理动态研讨所(Institute for Biophysical Dynamics)组长--何四川大学学生应邀访谈切磋所并设置学术讲座。讲座的主题素材为:Reversible methylation of DNA and WranglerNA in biological regulation 雷晓光大学生主持讲座。

告知标题:Gene expression regulation by 哈弗NA Methylation

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报告人:杨运桂 大学生,中国中国科学技术大学学招聘录用斟酌员

Abstract:

告诉时间:3月6日凌晨 10:00

Reversible chemical modifications on nucleic acids and proteins determine cell fates.The five bases that comprise nucleic acids ─ adenine, guanine, cytosine, thymine, and uracil ─ can be chemically and enzymatically modified.These chemical events can have significant biological consequences, particularly for gene expression.I will present chemical strategies we have developed to enrich, sequence, and study novel nucleic acid modifications that include 5-hydroxymethylcytosine and its further oxidized forms in mammalian genome.I will also present intriguing mammalian oxygenases that mediate nucleic acids oxidation.Some of these proteins play critical roles in obesity/diabetes and human diseases.We have discovered demethylation of mammalian messenger RNA catalyzed by some of these intriguing enzymes.Further, we have found and characterized reader proteins that selectively bind methylated mRNAs and mediate mRNA localization to affect their stability and translatability. Based on these discoveries we propose a new mode of biological regulation that depends on reversible RNA methylation.

报告地方:化西210

报告人简单介绍:

一九九七年文化人结束学业于浙大大学生命科学大学;三千年博士卒业于中科院法国巴黎药物研商所; 两千年国际癌症商讨署学士后/Staff Scientist; 二〇〇五年United Kingdom癌症研讨署硕士后;二〇〇四年中科院香水之都基因组讨论所商讨员。

研发昂CoraNA化学修饰德州仪器量测序和分析本领,系统钻研EvoqueNA双环戊二烯化特征及其修饰酶,声明其效能及人类疾病关联的调整机制。出席意识 SportageNA加氢苯转移酶和去丁二烯酶,表明 EnclaveNA 丁二烯化的动态可逆性,揭破其调控基因剪接和出核等新机制,及EvoqueNA十五烷化调节干细胞定向分歧和团体器官发育等首要效率。

告知摘录:

Over 100 types of chemical modifications have been identified in various types of RNAs including non-coding RNA and mRNA, among which methylation is the most common modification. The N6- methyl-adenosine and N5-methyl-cytosine are the most common and abundant internal modifications on mRNA molecules. The recent identification of methyltransferases METTL3/METTL14/WTAP and NSUN2, and m6A demethylases ALKBH5 and FTO, supports the reversibility of RNA methylation. Several YTH-domain-containing proteins YTHDF1-3 and YTHDC1-2 specifically binding to m6A and ALYREF recognizing m5C have been identified to regulate various mRNA processing, suggesting vital roles of RNA modifications in gene expression control. Our recent works revealed indispensable roles of m6A in mRNA translation, spermatogonial differentiation, and haematopoietic stem and progenitor cell specification, and 5-methylcytosine promotes mRNA export. We have further performed RNA-BisSeq to map transcriptomic profiles of m5C in early embryos of Zebra fish and human cancers. We will discuss the recent progress in RNA modifications and their potential biological significance in this seminar.

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